Senior Scientist, Computational Biology

  • Cambridge, Massachusetts
  • Work experience
  • Research, development, teaching
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Senior Scientist, Computational Biology

Become Part of the BioNTech Family.

Based in Cambridge, MA, BioNTech US serves as BioNTech’s North American headquarters and is an important part of our global effort to pioneer the development of next-generation immuno-oncology therapies. BioNTech US is a fully integrated subsidiary with a strong foundation in Europe and a focus on the development of novel neoantigen-targeted T cell therapies, complementing BioNTech’s highly innovative scientific approach and diversified pipeline of transformative cancer medicines. As a key research and clinical development hub, BioNTech US will enable BioNTech’s growing presence in the US.

We seek an innovative, collaborative, and enthusiastic Senior Scientist to be a part of the Computational Biology research team at BioNTech US. Our team aims to understand immune responses in cancer and infectious disease settings and find targets for novel vaccines and therapeutics. A successful candidate will work in a multidisciplinary environment together with teams of immunologists and molecular biologists to identify and validate targets in immuno-oncology, cell therapy, and infectious diseases. 

Here, you’ll achieve greatness.

Primary responsibilities include: 
-    Analysis of large in-house OMICs and mass spectrometry datasets to enable target discovery for oncology, with a focus on HLA-I/II ligandomics and the development of TCR-based therapies. Specific areas of focus will include:
o    Comparison and optimization of new search approaches; implementing search approaches for diverse mass spectrometry data types
o    Extending search space to cover new antigen classes (non-canonical protein sequences, PTMs, etc.). Implementing large-scale re-search of internal and external data repositories.
o    Ad hoc investigations to support go/no-go decisions related to candidate targets
o    Improvement and maintenance of our data resources in collaboration with the proteomics and data engineering teams
-    Development of machine learning algorithms to enhance the efficiency of peptide identification, including de novo-based methods; participation in an external machine learning collaboration 
-    Support for interdisciplinary teams (computational biology, proteomics, biochemistry, and immunology) working on target discovery for cancer and on new mRNA vaccines for infectious disease.

What you have to offer.

•    Ph.D. in bioinformatics, biology, computer science, mathematics, physics, or a related field
•    Proficiency with Python (preferred) or R and experience using GitHub to develop code collaboratively
•    Project-based experience working with mass spectrometry data, especially the analysis, comparison, or development of spectral search methods
•    Project-based experience related to machine learning, especially neural networks and deep learning
•    Strong communication and organizational skills
•    Preferred:  Basic understanding of immunology and cancer
•    Preferred:  Experience with AWS, with a focus on HPC computing

Benefits for you.

BioNTech US is committed to the well being of our team members and offers a variety of benefits supporting our diverse employee base. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:
  • Medical, Dental and Vision Insurance
  • Life, AD&D, STD and LTD Insurance
  • HSA & FSA Spending Accounts
  • Health & Wellness, including free onsite gym access
  • Adoption & Surrogacy Assistance
  • Vacation and Unlimited Sick Time
  • Holidays and Floating Holidays, including discretionary winter shutdown
  • 401(K) Plan with Significant Company Match
  • Tuition Reimbursement and Professional Development
  • Commuting Assistance and subsidized parking
  • Discounted Home and Auto Insurance
  • Pet Insurance
Plus more benefits that will be shared upon hire!

Have we kindled your pioneering spirit?

Then apply now for our location Cambridge (Boston) and simply send us your application documents using our online form.

For those who require assistance due to disability, or have questions prior to applying, please email

*BioNTech does not differentiate on the basis of gender, race or ethnicity, religion, color, sexual orientation or identity, disability, age and other protected statuses as given by applicable law. We are committed to creating a diverse environment and are proud to be an equal opportunity employer. Most important – it’s a match!