Senior Research Associate, Biologics Discovery

  • BioNTech Careers
  • Cambridge, Massachusetts
  • Work experience
  • Research, development, teaching
  • Published: 2022-09-15
  • published till: 2022-11-30
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Senior Research Associate, Biologics Discovery

BioNTech is a Germany-based biotechnology company with U.S. offices in Cambridge, MA and Gaithersburg, MD, that focuses on developing cancer therapeutics, including individualized immunotherapy, as well as vaccines for infectious diseases, including COVID-19. The company’s oncology pipeline contains several classes of drugs, including mRNA-based drugs to encode antigens, neoantigens, cytokines, and antibodies; cell therapies; bispecific antibodies; and small-molecule immunomodulators. BioNTech is partnered with several large pharmaceutical companies, including Roche, Eli Lilly, Pfizer, Sanofi, and Genmab. Comirnaty (COVID-19 vaccine) is its first commercialized product.

BioNTech US is seeking a passionate, creative, and curious Senior Research Associate to join the Biochemistry group. The successful candidate will collaborate on highly impactful, global infectious disease programs and work both independently and as part of a team to help establish technological capabilities centered around the core components of the immunological synapse – the T cell receptor (TCR) and Major Histocompatibility Complex (MHC). This role will focus on the characterization, screening and validation of crucial proteins for oncology research programs in downstream immunological assays.

Here, you’ll achieve greatness.

  • Human cell line husbandry; shaking (Expi293, CHO) and adherent tumor cell lines
  • Expression and purification of recombinant proteins from eukaryotic (predominantly Expi293 cells) and prokaryotic cell systems using affinity, ion exchange, and size exclusion chromatographic techniques
  • Deploy and analyze in vitro and in vivo experimental models of target cell killing mediated by biologics in the field of oncology
  • Analysis and presentation of results to larger scientific groups in the company.
  • Productivity both as part of a team and as an independent scientist such that milestones are accomplished against timelines
  • Keep a very well documented electronic notebook and maintain overall physical organization of relevant materials such as DNA constructs

What you have to offer.

  • Bachelors or Masters degree in biomedical sciences (immunology, biochemistry, biotechnology, cell biology, or molecular biology)
  • At least 2-4 years of relevant, post-degree research and/or pharmaceutical/biotechnology industry experience.  Experience working with biologics, antibodies and in the immunotherapy field is a plus
  • Experience in subculturing mammalian cell lines requiring aseptic techniques (such as proper biosafety cabinet operation)
  • Experience with cell-mediated cytotoxicity assays (Incucyte/xCELLIGENCE)
  • Proficiency in flow cytometry analysis of engineered and primary cells (6 colors or more)
  • Expertise in protein characterization techniques, such as SDS-PAGE, Western blot and ELISA
  • Hands-on experience with and a strong understanding of protein expression (particularly with large format shaking Expi293 cells) and purification (AKTA purification via affinity, size exclusion chromatography, ion exchange, etc.) strategies and fundamentals
  • Effectively work both as part of a team and as an independent scientist
  • Excellent organizational and communication skills, as well as attention to detail
  • Pro-active mentality and interest in exploring new scientific and conceptual realms
  • Ability to maintain inventories of equipment, supplies, and related research materials
    Preferred Requirements:
  • Experience implementing automation and liquid handling in cell-based assays
  • Background knowledge in field of Immunology

Benefits for you.

BioNTech US is committed to the well being of our team members and offers a variety of benefits supporting our diverse employee base. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:
  • Medical, Dental and Vision Insurance
  • Life, AD&D, STD and LTD Insurance
  • HSA & FSA Spending Accounts
  • Health & Wellness, including free onsite gym access
  • Adoption & Surrogacy Assistance
  • Vacation and Unlimited Sick Time
  • Holidays and Floating Holidays, including discretionary winter shutdown
  • 401(K) Plan with Significant Company Match
  • Tuition Reimbursement and Professional Development
  • Commuting Assistance and subsidized onsite parking
  • Discounted Home and Auto Insurance
  • Pet Insurance
Plus more benefits that will be shared upon hire!

Have we kindled your pioneering spirit?

Then apply now for our location Cambridge (Boston) and simply send us your application documents using our online form.

For those who require assistance due to disability, or have questions prior to applying, please email

*BioNTech does not differentiate on the basis of gender, race or ethnicity, religion, color, sexual orientation or identity, disability, age and other protected statuses as given by applicable law. We are committed to creating a diverse environment and are proud to be an equal opportunity employer. Most important – it’s a match!