Senior DMPK Scientist* as Associate Director* Non-Clinical Safety

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Become a member of the BioNTech Family!

As a part of our team of more than 3.000 pioneers, you will play a key role in developing solutions for some of the most crucial scientific challenges of our age. Within less than a year, we were able to develop our COVID-19 mRNA vaccine following the highest scientific and ethical standards – writing medical history.
 
We aim to reduce the suffering of people with life-changing therapies by harnessing the potential of the immune system to develop novel therapies against cancer and infectious diseases. While doing so, we are guided by our three company values: united, innovative, passionate. Get in touch with us if you are looking to be a part of creating hope for a healthy future in many people's lives.

Senior DMPK Scientist* as Associate Director* Non-Clinical Safety

At BioNTech, you will contribute to non-clinical development and safety activities for global R&D programs and new technology platforms during different stages of pharmaceutical development by implementing strategic drug metabolism and pharmacokinetics (DMPK) paths. BioNTech is expanding its activities towards new therapeutic modalities in different disease areas. With your activities you will enable clinical translation of our first-in-class immunotherapeutics and vaccines by the assessment of absorption, distribution, metabolism, excretion and pharmacokinetics (ADME/PK) of biologics and novel excipients. Your duties in detail:
  • Provide leadership, develop and execute effective non-clinical ADME and PK strategies from early discovery through clinical development and registration
  • Plan, design, execute and report program-specific non-clinical pharmacokinetic (ADME) studies to support development and rapid registration of BioNTech products
  • Manage interactions with external CROs to ensure high quality and on-time execution of DMPK studies
  • Delivery of project goals through interpretation of results and integration of data with other disciplines to contribute to decision making
  • Authoring and review of critical modules for submission packages (Investigator Brochure, IND, scientific advices, regulatory requests) and representation of pharmacokinetic and DMPK in global health authority interactions
  • Partnering with research leads for the design and data analysis/interpretation of pharmacokinetic (PK), toxicokinetic and pharmacodynamics (PD) aspects of preclinical studies
  • Aligning program-specific and platform overarching pharmacokinetic activities in cross-functional teams with pre-clinical and clinical stakeholders

What you have to offer.

  • Degree in life sciences, pharmacy, bioanalytical sciences, pharmacokinetics or equivalent. Preferably advanced degree incl. PhD/MD/VMD
  • Several years of experience in the biotechnology or pharmaceutical industry including a strong understanding of early and late drug development process in ADME and DMPK
  • A track record of transitioning projects from discovery to the early and late clinical stages in cross-functional program teams in a matrix environment
  • Able to demonstrate successful prediction of PK and PK/PD relationships based on preclinical data
  • Experience in the design and oversight of in vitro and in vivo DMPK studies, review and summarize results, integrate ADME, PK, and PK/PD information to guide development team
  • Experience executing DMPK studies with external vendors, incl. delivering high-quality data, tracking performance, and collaborating effectively
  • Proficient in using Phoenix WinNonlin for PK calculations/NCA. Familiarity with other PK/PD and modeling software like R, NONMEM, MATLAB is a plus

Benefits for you.

  • Company Pension Scheme
  • Childcare
  • Jobticket
  • Company Bike
  • Leave Account
  • Fitness Courses
  • Mobile Office
  • Special Vacation
... and much more.

Have we kindled your pioneering spirit?

Then apply now for our location Mainz and simply send us your application documents using our online form.

If you have any further questions, our Talent Acquisition Team will be happy to answer them on + 49 (0) 6131-9084-1291 (monday-friday, from 12 noon to 4 pm).

Job-ID 6731 (please indicate for inquiries)

We look forward to your application!

*BioNTech does not differentiate on the basis of gender, race or ethnicity, religion, color, sexual orientation or identity, disability, age and other protected statuses as given by applicable law. We are committed to creating a diverse environment and are proud to be an equal opportunity employer. Most important – it’s a match!

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