Senior Computational Biologist, Systems Immunology*

  • Cambridge, Massachusetts
  • Work experience
  • Research, development, teaching
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Senior Computational Biologist, Systems Immunology*

Become Part of the BioNTech Family.

Based in Cambridge, MA, BioNTech US serves as BioNTech’s North American headquarters and is an important part of our global effort to pioneer the development of next-generation immuno-oncology therapies. BioNTech US is a fully integrated subsidiary with a strong foundation in Europe and a focus on the development of novel neoantigen-targeted T cell therapies, complementing BioNTech’s highly innovative scientific approach and diversified pipeline of transformative cancer medicines. As a key research and clinical development hub, BioNTech US will enable BioNTech’s growing presence in the US.

We believe computational biologists are central to modern biological research. We are seeking an innovative, collaborative, and enthusiastic senior computational biologist to work with us on a variety of high-dimensional bioinformatics projects centered on target identification, therapeutic design, and translational research. The successful candidate will be tackling challenges in understanding the immune system, and how to harness it to develop novel prophylactics and therapeutics. Our new computational biologist will work closely with immunologists and molecular biologists both in the Systems Immunology team, and across teams at the broader BioNTech US research team. Key part of the role would be to design and analyze multimodal genomics experimental data, develop analysis strategies and tools to filter and distill in-house and large public datasets into focused hypotheses that drive target discovery, validation, and therapeutic approach. At BioNTech US, we are at the cutting-edge of infectious disease and cancer immunotherapy research. Our new senior computational biologist in Systems Immunology will be a critical thought leader in the company and will help tackle challenges at the forefront of cancer and infectious disease.

Here, you’ll achieve greatness.

Supporting BioNTech’s R&D team in the US by:
  • Identify novel targets for infectious disease and cancer immunotherapy by utilizing integrative bioinformatic approaches to multi-modal omics datasets
  • Work with advanced genomic data (single cell multi omic data, RNAseq, TCRseq, WES) to understand and impact immune cell phenotypes in disease settings
  • Propose and shape elegant experiments and data interpretation through close collaboration with experimental scientists
  • Leverage in-house and large public datasets to identify novel infectious disease targets, and enhance target selection and validation
  • Generate mechanistic hypotheses about response and resistance to novel immunotherapies using genomic and immunological patient-derived data.
  • Develop innovative, robust, analysis pipelines that can be applied in research and clinical settings
  • Liaise with experts in immunology, clinical medicine, infectious disease, and software engineering as a project team member and provide expertise as a scientific resource for key company programs
  • Identify, develop, manage, and contribute to collaborations and partnerships

What you have to offer.

  • Minimum requirements; Ph.D. in bioinformatics, computational biology, systems biology/immunology, or a related discipline with a strong record of publications/patents is required. Industry or academic experience post-PhD is preferred.
  • Experience developing and optimizing NGS-based tools for cancer, immunology and/or infectious disease research (e.g., gene expression, lineage reconstruction and phylogenies).
  • Familiarity with single-cell sequencing approaches and data analysis would be is a significant plus.
  • Use of Linux in a cluster-computing environment.
  • Fluency in R and/or Python (strictly required).
  • Demonstrated ability to formulate and test hypotheses for potential targets or biomarkers by designing and implementing novel computational approaches
  • Familiarity with the basics of immunology; specific expertise in infectious disease, TCR repertoire analysis or TCR recognition mechanisms would be a significant plus
  • Capacity to prioritize and work independently to complete tasks and advance projects with minimal supervision
  • Experience with mining public data sets, such as TCGA, GTEx, CCLE or pathogen-based databases
  • Strong written and verbal skills; ability to translate and communicate complex information and concepts for scientists of diverse backgrounds
  • Positive and collaborative attitude; ability to work effectively with internal and external collaborators and multidisciplinary teams composed of scientists and non-scientists to translate emerging research to guide internal programs
  • Capacity to prioritize and work independently to complete tasks and advance projects with minimal supervision
  • Creative and innovative thinking; track record of thought leadership

Benefits for you.

BioNTech US is committed to the well being of our team members and offers a variety of benefits supporting our diverse employee base. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:
  • Medical, Dental and Vision Insurance
  • Life, AD&D, STD and LTD Insurance
  • HSA & FSA Spending Accounts
  • Free COVID-19 Testing 
  • Health & Wellness, including free onsite gym access
  • Adoption & Surrogacy Assistance
  • Vacation and Unlimited Sick Time
  • Holidays and Floating Holidays, including discretionary winter shutdown
  • 401(K) Plan with Significant Company Match
  • Tuition Reimbursement and Professional Development
  • Commuting Assistance and free onsite parking
  • Discounted Home and Auto Insurance
  • Pet Insurance
Plus more benefits that will be shared upon hire!

Have we kindled your pioneering spirit?

Then apply now for our location Cambridge (Boston) and simply send us your application documents using our online form.

For those who require assistance due to disability, or have questions prior to applying, please email

*BioNTech does not differentiate on the basis of gender, race or ethnicity, religion, color, sexual orientation or identity, disability, age and other protected statuses as given by applicable law. We are committed to creating a diverse environment and are proud to be an equal opportunity employer. Most important – it’s a match!