Scientist / Senior Scientist, Computational Biology*

  • Cambridge, Massachusetts
  • Work experience
  • Research, development, teaching
scheme image

Scientist / Senior Scientist, Computational Biology*

Become Part of the BioNTech Family.

Based in Cambridge, MA, BioNTech US serves as BioNTech’s North American headquarters and is an important part of our global effort to pioneer the development of next-generation immuno-oncology therapies. BioNTech US is a fully integrated subsidiary with a strong foundation in Europe and a focus on the development of novel neoantigen-targeted T cell therapies, complementing BioNTech’s highly innovative scientific approach and diversified pipeline of transformative cancer medicines. As a key research and clinical development hub, BioNTech US will enable BioNTech’s growing presence in the US.

At BioNTech US, our computational biologists are at the heart of our research. We are seeking an innovative, collaborative, and enthusiastic computational biologist to work with us on a variety of high-dimensional bioinformatics projects centered on target identification, drug discovery, and translational research. The individual will integrate clinical and research datasets, including mass spectrometry and next-generation sequencing data. The successful candidate will develop novel methods, analysis strategies, and tools to filter and distill multi-dimensional datasets into focused hypotheses that drive clinical and discovery research. A critical component of the role will be close collaboration with multi-disciplinary internal discovery teams and collaborators from across the fields of oncology, immunology and clinical research. At BioNTech US, we are at the cutting-edge of immunotherapy research, emphasizing participation in conferences and authorship of high-impact publications. Our new computational biologist will be a critical thought leader in the company, collaborating closely with discovery and development scientists.


Here, you’ll achieve greatness.

Supporting BioNTech’s R&D team in the US by:
  • Identify novel immuno-oncology targets by utilizing integrative approaches to multi-modal omics datasets
  • Drive antigen discovery to feed vaccine and cellular therapies pipelines (including CAR, TCR, and ex vivo induced T cells) at BioNTech as a whole
  • Conduct correlative analysis of patient outcomes, phenotypes, and immune readouts with diverse high dimensional data types to identify biomarkers and mechanistic hypotheses about response and resistance to novel immunotherapies.
  • Contribute to the development and benchmarking of new neoantigen prediction algorithms
  • Develop innovative, robust, analysis pipelines that can be applied in research and clinical settings
  • Liaise with experts in immunology, clinical medicine, infectious disease, machine learning experts, and software engineering as a project team member and provide expertise as a scientific resource for key company programs
  • Identify, develop, manage, and contribute to collaborations and partnerships
  • Provide guidance on experimental design and data interpretation by engaging lab scientists
  • Serve as a project team member and a scientific resource for key company programs

What you have to offer.

  • Minimum requirements; Ph.D. in bioinformatics, computational biology, systems biology, or a related discipline with a strong record of publications/patents is required.
  • Experience developing and optimizing NGS-based software for cancer and/or immunology research (e.g., variant calling, gene expression, epigenetic analyses, single-cell sequencing approaches).
  • Fluency in SAM/BAM file format specifications and other standard bioinformatic formats.
  • Proficiency with the following: 
    • Use of Linux in a cluster-computing environment.
    • Experience applying statistical fundamentals to biological datasets.
    • Fluency in Python and/or R (strictly required).
  • Experience integrating diverse NGS and non-NGS data sets to identify cancer drivers, predictive biomarkers, or mechanistic hypotheses
  • Experience with mining public data sets, such as TCGA, GTEx, and CCLE
  • Demonstrated ability to formulate and test hypotheses by designing and implementing novel computational approaches
  • Capacity to prioritize and work independently to complete tasks and advance projects with minimal supervision
  • Ability to work effectively with collaborators and multidisciplinary teams composed of scientists and non-scientists to translate emerging research to guide internal programs
  • Strong written and verbal skills; ability to translate and communicate complex information and concepts for scientists of diverse backgrounds
  • Positive and collaborative attitude; ability to work effectively with internal and external collaborators and multidisciplinary teams composed of scientists and non-scientists to translate emerging research to guide internal programs
  • Capacity to prioritize and work independently to complete tasks and advance projects with minimal supervision
  • Creative and innovative thinking; track record of thought leadership
      Preferred Qualifications
  • Familiarity with the basics of immunology; specific expertise in infectious disease and/or TCR repertoire analysis would be a significant plus
  • Experience with structural biology and molecular dynamics (e.g. Rosetta)
  • Experience implementing neural networks, logistic regression, and other machine learning approaches.

Benefits for you.

BioNTech US is committed to the well being of our team members and offers a variety of benefits supporting our diverse employee base. Salaried/Position-Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:
  • Medical, Dental and Vision Insurance
  • Life, AD&D, STD and LTD Insurance
  • HSA & FSA Spending Accounts
  • Free COVID-19 Testing 
  • Health & Wellness, including free onsite gym access
  • Adoption & Surrogacy Assistance
  • Vacation and Unlimited Sick Time
  • Holidays and Floating Holidays, including discretionary winter shutdown
  • 401(K) Plan with Significant Company Match
  • Tuition Reimbursement and Professional Development
  • Commuting Assistance and free onsite parking
  • Discounted Home and Auto Insurance
  • Pet Insurance
Plus more benefits that will be shared upon hire!

Have we kindled your pioneering spirit?

Then apply now for our location Cambridge (Boston) and simply send us your application documents using our online form.

For those who require assistance due to disability, or have questions prior to applying, please email

*BioNTech does not differentiate on the basis of gender, race or ethnicity, religion, color, sexual orientation or identity, disability, age and other protected statuses as given by applicable law. We are committed to creating a diverse environment and are proud to be an equal opportunity employer. Most important – it’s a match!